D-Ribose has already been widely studied, and invariably the studies show that it has multiple beneficial properties.
Here we collate and archive extracts of research and experience with various versions of Ribose. First we quote the source of the information, then we quote the research. There is a lot more info on http://scholar.google.com.
From: The Internet Journal of Pulmonary Medicine™ ISSN: 1531-2984 (http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpm/vol7n2/ribose.xml)
D-Ribose Benefits COPD [Chronic Obstructive Pulmonary Disease]
"Progressive COPD produces clinical deterioration of both the lungs and heart. DR may potentially offer a benefit to both of these organs. The pulmonary measured parameters revealed substantial improvement with DR, but a controlled study of COPD patients is necessary to further substantiate this finding."
From a Chronic Fatigue Blog: (http://rockycha.wordpress.com/2008/01/28/chronic-fatigue-and-post-holiday-recovery/)
"Two things that I’ve noticed during this holiday recovery period: taking my NT Factor diligently didn’t prevent or dissuade the CFS reactions I received from my naughty diet. But, increasing my D-Ribose DID help my muscle pain. This supplement always seems to have results the next day, if not within hours. I have to be careful taking the d-ribose though, if I take it as recommended (1 teaspoons 3 times a day), I get wired and can’t sleep. It’s a natural sugar, after all. When my diet is good and I’m feeling better like I do now, I only take 1tsp a day."
From: www.ImmuneSupport.com
Research: Benefit of Ribose in a Patient With Fibromyalgia 01-31-2005
Journal: Pharmacotherapy
Posted on MedScape 01/07/2005
Benjamin Gebhart, Pharm.D.; James A. Jorgenson, M.S., FASHP
"Abstract
Ribose was added to the existing treatment regimen of a woman with fibromyalgia, resulting in a decrease in symptoms. It has been postulated that patients with fibromyalgia may have an alteration in muscle adenine nucleotide metabolism, leading to depleted energy reserves and an imbalance in cellular adenosine-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge. As a key component in adenine nucleotide synthesis, ribose supplementation may be useful in such patients.
Introduction
Fibromyalgia is a syndrome that is manifested by generalized muscle pain and additional systemic symptoms of fatigue, tenderness and stiffness in multiple joints, sleep disturbance, and alterations in bowel activity.
The specific etiology is unknown; however, changes in muscle histology, energy metabolism, oxygen utilization, and the neuroendocrine stress-response system have been postulated to play a role in the development and persistence of this disorder. Low levels of muscle adenine nucleotides, reflected in depleted energy reserves and an imbalance in cellular adenosine 5'-triphosphate:adenosine 5'-diphosphate:adenosine 5'-monophosphate (ATP:ADP:AMP) ratios with an abnormal energy charge, have been reported. The unknown cause and varying presenting symptoms make fibromyalgia a therapeutic challenge for practitioners.
The management of patients with fibromyalgia requires the integration of both pharmacologic and nonpharmacologic approaches. Pharmacologic options have included tricyclic antidepressants, selective serotonin receptor antagonists, analgesics, benzodiazepines, antiinflammatory agents, and corticosteroids.
Routine daily exercise programs, dietary modifications, alternative therapies such as biofeedback and hypnotherapy, and nutraceuticals such as S-adenosyl-L-methionine (SAMe) have also been explored.Unfortunately, less than 50% of patients achieve any meaningful relief of their symptoms with use of those therapies.
We describe the case of a patient with fibromyalgia who had symptomatic relief when ribose was added to her existing treatment regimen. There have been anecdotal reports on the benefits of ribose in patients with fibromyalgia in whom conventional therapies have failed; however, to our knowledge, this is the first published case of use of ribose for this syndrome.
Case Report
A 37-year-old woman had daily episodes of intense musculoskeletal pain and stiffness, mental "cloudiness," bouts of diarrhea, and sleep disturbance. As she was a surgeon, these symptoms compromised the skills necessary to perform her daily duties in the operating room. She was diagnosed with fibromyalgia by exclusion of other diseases and syndromes and in accordance with the American College of Rheumatology criteria.
The patient was treated with ibuprofen 800 mg twice/day, valdecoxib 10 mg once/day, diphenhydramine 50 mg-acetaminophen 1000 mg at bedtime, and physical therapy once/day. She stated that this therapeutic regimen had limited benefit and that the adverse effects from these drugs further impaired her ability to perform her operative duties.
Approximately 7 months later, in addition to her regular drug therapy, the patient began taking CORvalen (Bioenergy, Inc., Ham Lake, MN), a ribose-based product. She took 5g of CORvalen mixed in water twice/day. She experienced no adverse effects, and after 14 days she reported a decrease in her symptoms. Specifically, she noted an improvement in sleep, mental alertness, a marked decrease in joint pain, and normal stools. This trend continued, and after an additional month of CORvalen therapy she reported near-normal functioning with a major reduction in her symptoms.
After another month of taking CORvalen and feeling "normal," the patient elected to discontinue the drug. Within 7 days, she regressed to her initial fibromyalgia state, as reflected in joint pain, sleep disturbance, morning stiffness, trigger-point flares, and diarrhea. She resumed taking CORvalen, at the same dosage as before, and a major reduction in her symptoms again occurred within 14 days. She noted continual benefit for the next month while taking CORvalen. She stopped taking the drug for a second time after this additional 30-day period, and once again she experienced a reemergence of symptoms. When CORvalen was restarted for a third time, the patient's symptoms again subsided.
At the time of this writing, the patient was continuing to take CORvalen [a form of D-Ribose] and was satisfied that her symptoms had abated."
From www.bioenergy.com
Can a simple sugar provide relief for the millions of patients afflicted with the diagnosis of fibromyalgia and/or chronic fatigue? That's what Jacob Teitelbaum, MD, and Valen Labs wanted to determine with an open label, 41-patient feasibility study, the results of which are now being released.
The study had two endpoints: assessing the level of relief in symptoms of fatigue and pain; and determining changes in patient quality of life.
The patients in the study had an average age of 48 years and were 78-percent female, which is in keeping with the general population as fibromyalgia and chronic fatigue syndrome affect twice as many women as men and typically first appears at middle age.
At the start of the study the patients completed a 10-point Quality Of Life visual analog scale and then took five grams of CORvalen™ D-ribose orally, three times a day, for an average of 28 days.
After the 28-day treatment period the QOL questionnaire was repeated, and 69-percent of the 36 patients who completed the course of CORvalenTM treatment had significant improvement in their symptoms. They also averaged a 25-percent improvement in the QOL scale.
From Health Library (http://healthlibrary.epnet.com)
"Ribose may be of benefit in improving exercise tolerance in people with angina by helping the heart regenerate its ATP, but the evidence that it works remains highly preliminary. One small study found evidence that ribose supplements might improve heart function in people with congestive heart failure.
Sports enthusiasts are more interested in ATP's effects on regular muscles than on the heart muscle. At least one animal study seems to show that skeletal muscle, like heart muscle, replenishes ATP more quickly when ribose is added to the blood. In theory, this could lead to enhanced performance in high intensity anaerobic exercise, such as sprinting. However, six small double-blind, placebo-controlled trials in humans failed to find any benefit. In one of these studies, dextrose (a form of ordinary sugar) proved effective while ribose did not.
In one small, double-blind study, ribose failed to prove effective for enhancing mental function The researchers suggest that the dose they used (2 g daily) may have been insufficient.
In a few case reports, ribose apparently has produced an increase in exercise ability in people with a rare condition involving deficiency of the enzyme myoadenylate deaminase (AMPD). However, no double-blind studies of ribose in AMPD deficiency have been conducted. Small, double-blind studies have failed to find ribose effective for another rare enzyme deficiency, called McArdle's disease, or for Duchenne's muscular dystrophy.
Individuals with sufficiently severe coronary artery disease suffer reduced blood flow to the heart (ischemia) with exercise, and experience angina pain. One small study examined whether giving ribose can improve exercise tolerance for people with angina. In the study, 20 men with severe coronary artery disease walked on a treadmill while researchers noted how long it took for signs of ischemia to develop. For the next 3 days, the men took either oral ribose (60 mg per day) or placebo, after which they repeated the treadmill test. Results of the final test showed that those taking ribose increased the time they were able to walk before developing EKG signs of ischemia, while those taking placebo had no such improvement. This preliminary study was too small to prove anything definitively, but it certainly suggests that further investigation would be worthwhile.
Another small placebo-controlled study enrolled people with coronary artery disease and congestive heart failure and found that use of ribose supplements improved objective measures of heart function and also enhanced subjective quality of life ."
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